AustralieFrV1, Main, Exploration, bibRecord, 003A52

Der p 11 Is a Major Allergen for House Dust Mite-Allergic Patients Suffering from Atopic Dermatitis

Identifieur interne : 003A52 ( Main/Exploration ); précédent : 003A51; suivant : 003A53

Der p 11 Is a Major Allergen for House Dust Mite-Allergic Patients Suffering from Atopic Dermatitis

Auteurs : Srinita Banerjee [Autriche] ; Yvonne Resch [Autriche] ; Kuan-Wei Chen [Autriche] ; Ines Swoboda [Autriche] ; Margit Focke-Tejkl [Autriche] ; Katharina Blatt [Autriche] ; Natalija Novak [Allemagne] ; Magnus Wickman [Suède] ; Marianne Van Hage [Suède] ; Rosetta Ferrara [Italie] ; Adriano Mari [Italie] ; Ashok Purohit [France] ; Gabrielle Pauli [France] ; Elopy N. Sibanda [Zimbabwe] ; Portia Ndlovu [Zimbabwe] ; Wayne R. Thomas [Australie] ; Vladislav Krzyzanek [République tchèque] ; Sebastian Tacke [Allemagne] ; Ursula Malkus [Allemagne] ; Peter Valent [Autriche] ; Rudolf Valenta [Autriche] ; Susanne Vrtala [Autriche]

Source :

The Journal of investigative dermatology [ 0022-202X ] ; 2014.

RBID : PMC:4636057

Descripteurs français

English descriptors

KwdEn :
- Adolescent, Adult, Amino Acid Sequence, Animals, Antibodies (blood), Antibodies (immunology), Antigens, Dermatophagoides (chemistry), Antigens, Dermatophagoides (genetics), Antigens, Dermatophagoides (immunology), Arthropod Proteins, Biomarkers, Child, Circular Dichroism, Dermatitis, Atopic (epidemiology), Dermatitis, Atopic (immunology), Dermatophagoides pteronyssinus (genetics), Dermatophagoides pteronyssinus (immunology), Female, Humans, Immunoglobulin E (blood), Immunoglobulin E (immunology), Male, Molecular Sequence Data, Protein Structure, Secondary, Seroepidemiologic Studies, Tropomyosin (chemistry), Tropomyosin (genetics), Tropomyosin (immunology), Young Adult.
MESH :
- chemical , blood : Antibodies, Immunoglobulin E.
- chemical , chemistry : Antigens, Dermatophagoides, Tropomyosin.
- chemical , genetics : Antigens, Dermatophagoides, Tropomyosin.
- chemical , immunology : Antibodies, Antigens, Dermatophagoides, Immunoglobulin E, Tropomyosin.
- epidemiology : Dermatitis, Atopic.
- genetics : Dermatophagoides pteronyssinus.
- immunology : Dermatitis, Atopic, Dermatophagoides pteronyssinus.
- Adolescent, Adult, Amino Acid Sequence, Animals, Arthropod Proteins, Biomarkers, Child, Circular Dichroism, Female, Humans, Male, Molecular Sequence Data, Protein Structure, Secondary, Seroepidemiologic Studies, Young Adult.

Abstract

House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from Dermatophagoides pteronyssinus (Der p 11) in HDM allergy. Sequence analysis showed that Der p 11 has high homology to paramyosins from mites, ticks, and other invertebrates. A synthetic gene coding for Der p 11 was expressed in Escherichia coli and rDer p 11 purified to homogeneity as folded, alpha-helical protein as determined by circular dichroism spectroscopy. Using antibodies raised against rDer p 11 and immunogold electron microscopy, the allergen was localized in the muscle beneath the skin of mite bodies but not in feces. IgE reactivity of rDer p 11 was tested with sera from HDM-allergic patients from Europe and Africa in radioallergosorbent test–based dot-blot assays. Interestingly, we found that Der p 11 is a major allergen for patients suffering from atopic dermatitis (AD), whereas it is only a minor allergen for patients suffering from respiratory forms of HDM allergy. Thus, rDer p 11 might be a useful serological marker allergen for the identification of a subgroup of HDM-allergic patients suffering from HDM-associated AD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636057

DOI: 10.1038/jid.2014.271
PubMed: 24999597
PubMed Central: 4636057

Affiliations:

Le document en format XML

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<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Focke Tejkl, Margit" sort="Focke Tejkl, Margit" uniqKey="Focke Tejkl M" first="Margit" last="Focke-Tejkl">Margit Focke-Tejkl</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blatt, Katharina" sort="Blatt, Katharina" uniqKey="Blatt K" first="Katharina" last="Blatt">Katharina Blatt</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Novak, Natalija" sort="Novak, Natalija" uniqKey="Novak N" first="Natalija" last="Novak">Natalija Novak</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Department of Dermatology and Allergy, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Dermatology and Allergy, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wickman, Magnus" sort="Wickman, Magnus" uniqKey="Wickman M" first="Magnus" last="Wickman">Magnus Wickman</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Sachs’ Children’s Hospital and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Sachs’ Children’s Hospital and Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Hage, Marianne" sort="Van Hage, Marianne" uniqKey="Van Hage M" first="Marianne" last="Van Hage">Marianne Van Hage</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital Stockholm, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital Stockholm, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ferrara, Rosetta" sort="Ferrara, Rosetta" uniqKey="Ferrara R" first="Rosetta" last="Ferrara">Rosetta Ferrara</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Center for Molecular Allergology, IDI-IRCCS, Rome, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Center for Molecular Allergology, IDI-IRCCS, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mari, Adriano" sort="Mari, Adriano" uniqKey="Mari A" first="Adriano" last="Mari">Adriano Mari</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Center for Molecular Allergology, IDI-IRCCS, Rome, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Center for Molecular Allergology, IDI-IRCCS, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Purohit, Ashok" sort="Purohit, Ashok" uniqKey="Purohit A" first="Ashok" last="Purohit">Ashok Purohit</name>
<affiliation wicri:level="3"><nlm:aff id="A8">Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pauli, Gabrielle" sort="Pauli, Gabrielle" uniqKey="Pauli G" first="Gabrielle" last="Pauli">Gabrielle Pauli</name>
<affiliation wicri:level="3"><nlm:aff id="A8">Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sibanda, Elopy N" sort="Sibanda, Elopy N" uniqKey="Sibanda E" first="Elopy N." last="Sibanda">Elopy N. Sibanda</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Gamma City Laboratory, Harare, Zimbabwe</nlm:aff>
<country xml:lang="fr">Zimbabwe</country>
<wicri:regionArea>Gamma City Laboratory, Harare</wicri:regionArea>
<wicri:noRegion>Harare</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ndlovu, Portia" sort="Ndlovu, Portia" uniqKey="Ndlovu P" first="Portia" last="Ndlovu">Portia Ndlovu</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Gamma City Laboratory, Harare, Zimbabwe</nlm:aff>
<country xml:lang="fr">Zimbabwe</country>
<wicri:regionArea>Gamma City Laboratory, Harare</wicri:regionArea>
<wicri:noRegion>Harare</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thomas, Wayne R" sort="Thomas, Wayne R" uniqKey="Thomas W" first="Wayne R." last="Thomas">Wayne R. Thomas</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Center for Child Health Research, Telethon Institute of Child Health Research, University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Center for Child Health Research, Telethon Institute of Child Health Research, University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krzyzanek, Vladislav" sort="Krzyzanek, Vladislav" uniqKey="Krzyzanek V" first="Vladislav" last="Krzyzanek">Vladislav Krzyzanek</name>
<affiliation wicri:level="3"><nlm:aff id="A11">Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno</wicri:regionArea>
<placeName><settlement type="city">Brno</settlement>
<region>Moravie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tacke, Sebastian" sort="Tacke, Sebastian" uniqKey="Tacke S" first="Sebastian" last="Tacke">Sebastian Tacke</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Physics and Biophysics, University of Münster, Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malkus, Ursula" sort="Malkus, Ursula" uniqKey="Malkus U" first="Ursula" last="Malkus">Ursula Malkus</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Physics and Biophysics, University of Münster, Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Valent, Peter" sort="Valent, Peter" uniqKey="Valent P" first="Peter" last="Valent">Peter Valent</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Valenta, Rudolf" sort="Valenta, Rudolf" uniqKey="Valenta R" first="Rudolf" last="Valenta">Rudolf Valenta</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2">Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vrtala, Susanne" sort="Vrtala, Susanne" uniqKey="Vrtala S" first="Susanne" last="Vrtala">Susanne Vrtala</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A13">Christian Doppler Laboratory for the Development of Allergen Chips, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Christian Doppler Laboratory for the Development of Allergen Chips, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of investigative dermatology</title>
<idno type="ISSN">0022-202X</idno>
<idno type="eISSN">1523-1747</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Antibodies (blood)</term>
<term>Antibodies (immunology)</term>
<term>Antigens, Dermatophagoides (chemistry)</term>
<term>Antigens, Dermatophagoides (genetics)</term>
<term>Antigens, Dermatophagoides (immunology)</term>
<term>Arthropod Proteins</term>
<term>Biomarkers</term>
<term>Child</term>
<term>Circular Dichroism</term>
<term>Dermatitis, Atopic (epidemiology)</term>
<term>Dermatitis, Atopic (immunology)</term>
<term>Dermatophagoides pteronyssinus (genetics)</term>
<term>Dermatophagoides pteronyssinus (immunology)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunoglobulin E (blood)</term>
<term>Immunoglobulin E (immunology)</term>
<term>Male</term>
<term>Molecular Sequence Data</term>
<term>Protein Structure, Secondary</term>
<term>Seroepidemiologic Studies</term>
<term>Tropomyosin (chemistry)</term>
<term>Tropomyosin (genetics)</term>
<term>Tropomyosin (immunology)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Animaux</term>
<term>Anticorps (immunologie)</term>
<term>Anticorps (sang)</term>
<term>Antigènes de Dermatophagoides ()</term>
<term>Antigènes de Dermatophagoides (génétique)</term>
<term>Antigènes de Dermatophagoides (immunologie)</term>
<term>Dermatophagoides pteronyssinus (génétique)</term>
<term>Dermatophagoides pteronyssinus (immunologie)</term>
<term>Dichroïsme circulaire</term>
<term>Données de séquences moléculaires</term>
<term>Eczéma atopique (immunologie)</term>
<term>Eczéma atopique (épidémiologie)</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunoglobuline E (immunologie)</term>
<term>Immunoglobuline E (sang)</term>
<term>Jeune adulte</term>
<term>Marqueurs biologiques</term>
<term>Mâle</term>
<term>Protéines d'arthropode</term>
<term>Structure secondaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>Tropomyosine ()</term>
<term>Tropomyosine (génétique)</term>
<term>Tropomyosine (immunologie)</term>
<term>Études séroépidémiologiques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies</term>
<term>Immunoglobulin E</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antigens, Dermatophagoides</term>
<term>Tropomyosin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Dermatophagoides</term>
<term>Tropomyosin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies</term>
<term>Antigens, Dermatophagoides</term>
<term>Immunoglobulin E</term>
<term>Tropomyosin</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dermatitis, Atopic</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dermatophagoides pteronyssinus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes de Dermatophagoides</term>
<term>Dermatophagoides pteronyssinus</term>
<term>Tropomyosine</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps</term>
<term>Antigènes de Dermatophagoides</term>
<term>Dermatophagoides pteronyssinus</term>
<term>Eczéma atopique</term>
<term>Immunoglobuline E</term>
<term>Tropomyosine</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dermatitis, Atopic</term>
<term>Dermatophagoides pteronyssinus</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps</term>
<term>Immunoglobuline E</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Eczéma atopique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Arthropod Proteins</term>
<term>Biomarkers</term>
<term>Child</term>
<term>Circular Dichroism</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Molecular Sequence Data</term>
<term>Protein Structure, Secondary</term>
<term>Seroepidemiologic Studies</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Animaux</term>
<term>Antigènes de Dermatophagoides</term>
<term>Dichroïsme circulaire</term>
<term>Données de séquences moléculaires</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Marqueurs biologiques</term>
<term>Mâle</term>
<term>Protéines d'arthropode</term>
<term>Structure secondaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>Tropomyosine</term>
<term>Études séroépidémiologiques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P3">House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from <italic>Dermatophagoides pteronyssinus</italic>
 (Der p 11) in HDM allergy. Sequence analysis showed that Der p 11 has high homology to paramyosins from mites, ticks, and other invertebrates. A synthetic gene coding for Der p 11 was expressed in <italic>Escherichia coli</italic>
 and rDer p 11 purified to homogeneity as folded, alpha-helical protein as determined by circular dichroism spectroscopy. Using antibodies raised against rDer p 11 and immunogold electron microscopy, the allergen was localized in the muscle beneath the skin of mite bodies but not in feces. IgE reactivity of rDer p 11 was tested with sera from HDM-allergic patients from Europe and Africa in radioallergosorbent test–based dot-blot assays. Interestingly, we found that Der p 11 is a major allergen for patients suffering from atopic dermatitis (AD), whereas it is only a minor allergen for patients suffering from respiratory forms of HDM allergy. Thus, rDer p 11 might be a useful serological marker allergen for the identification of a subgroup of HDM-allergic patients suffering from HDM-associated AD.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>France</li>
<li>Italie</li>
<li>République tchèque</li>
<li>Suède</li>
<li>Zimbabwe</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>District de Cologne</li>
<li>District de Münster</li>
<li>Grand Est</li>
<li>Latium</li>
<li>Moravie</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Svealand</li>
<li>Vienne (Autriche)</li>
</region>
<settlement><li>Bonn</li>
<li>Brno</li>
<li>Münster</li>
<li>Rome</li>
<li>Stockholm</li>
<li>Strasbourg</li>
<li>Vienne (Autriche)</li>
</settlement>
</list>
<tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Banerjee, Srinita" sort="Banerjee, Srinita" uniqKey="Banerjee S" first="Srinita" last="Banerjee">Srinita Banerjee</name>
</region>
<name sortKey="Blatt, Katharina" sort="Blatt, Katharina" uniqKey="Blatt K" first="Katharina" last="Blatt">Katharina Blatt</name>
<name sortKey="Chen, Kuan Wei" sort="Chen, Kuan Wei" uniqKey="Chen K" first="Kuan-Wei" last="Chen">Kuan-Wei Chen</name>
<name sortKey="Focke Tejkl, Margit" sort="Focke Tejkl, Margit" uniqKey="Focke Tejkl M" first="Margit" last="Focke-Tejkl">Margit Focke-Tejkl</name>
<name sortKey="Resch, Yvonne" sort="Resch, Yvonne" uniqKey="Resch Y" first="Yvonne" last="Resch">Yvonne Resch</name>
<name sortKey="Swoboda, Ines" sort="Swoboda, Ines" uniqKey="Swoboda I" first="Ines" last="Swoboda">Ines Swoboda</name>
<name sortKey="Swoboda, Ines" sort="Swoboda, Ines" uniqKey="Swoboda I" first="Ines" last="Swoboda">Ines Swoboda</name>
<name sortKey="Valent, Peter" sort="Valent, Peter" uniqKey="Valent P" first="Peter" last="Valent">Peter Valent</name>
<name sortKey="Valenta, Rudolf" sort="Valenta, Rudolf" uniqKey="Valenta R" first="Rudolf" last="Valenta">Rudolf Valenta</name>
<name sortKey="Valenta, Rudolf" sort="Valenta, Rudolf" uniqKey="Valenta R" first="Rudolf" last="Valenta">Rudolf Valenta</name>
<name sortKey="Vrtala, Susanne" sort="Vrtala, Susanne" uniqKey="Vrtala S" first="Susanne" last="Vrtala">Susanne Vrtala</name>
<name sortKey="Vrtala, Susanne" sort="Vrtala, Susanne" uniqKey="Vrtala S" first="Susanne" last="Vrtala">Susanne Vrtala</name>
</country>
<country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Novak, Natalija" sort="Novak, Natalija" uniqKey="Novak N" first="Natalija" last="Novak">Natalija Novak</name>
</region>
<name sortKey="Malkus, Ursula" sort="Malkus, Ursula" uniqKey="Malkus U" first="Ursula" last="Malkus">Ursula Malkus</name>
<name sortKey="Tacke, Sebastian" sort="Tacke, Sebastian" uniqKey="Tacke S" first="Sebastian" last="Tacke">Sebastian Tacke</name>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Wickman, Magnus" sort="Wickman, Magnus" uniqKey="Wickman M" first="Magnus" last="Wickman">Magnus Wickman</name>
</region>
<name sortKey="Van Hage, Marianne" sort="Van Hage, Marianne" uniqKey="Van Hage M" first="Marianne" last="Van Hage">Marianne Van Hage</name>
</country>
<country name="Italie"><region name="Latium"><name sortKey="Ferrara, Rosetta" sort="Ferrara, Rosetta" uniqKey="Ferrara R" first="Rosetta" last="Ferrara">Rosetta Ferrara</name>
</region>
<name sortKey="Mari, Adriano" sort="Mari, Adriano" uniqKey="Mari A" first="Adriano" last="Mari">Adriano Mari</name>
</country>
<country name="France"><region name="Grand Est"><name sortKey="Purohit, Ashok" sort="Purohit, Ashok" uniqKey="Purohit A" first="Ashok" last="Purohit">Ashok Purohit</name>
</region>
<name sortKey="Pauli, Gabrielle" sort="Pauli, Gabrielle" uniqKey="Pauli G" first="Gabrielle" last="Pauli">Gabrielle Pauli</name>
</country>
<country name="Zimbabwe"><noRegion><name sortKey="Sibanda, Elopy N" sort="Sibanda, Elopy N" uniqKey="Sibanda E" first="Elopy N." last="Sibanda">Elopy N. Sibanda</name>
</noRegion>
<name sortKey="Ndlovu, Portia" sort="Ndlovu, Portia" uniqKey="Ndlovu P" first="Portia" last="Ndlovu">Portia Ndlovu</name>
</country>
<country name="Australie"><noRegion><name sortKey="Thomas, Wayne R" sort="Thomas, Wayne R" uniqKey="Thomas W" first="Wayne R." last="Thomas">Wayne R. Thomas</name>
</noRegion>
</country>
<country name="République tchèque"><region name="Moravie"><name sortKey="Krzyzanek, Vladislav" sort="Krzyzanek, Vladislav" uniqKey="Krzyzanek V" first="Vladislav" last="Krzyzanek">Vladislav Krzyzanek</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003A52 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003A52 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4636057
   |texte=   Der p 11 Is a Major Allergen for House Dust Mite-Allergic Patients Suffering from Atopic Dermatitis
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24999597" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Der p 11 Is a Major Allergen for House Dust Mite-Allergic Patients Suffering from Atopic Dermatitis

Der p 11 Is a Major Allergen for House Dust Mite-Allergic Patients Suffering from Atopic Dermatitis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.